Principalities are generally formed when the ether in a person is thickened by sin and by transgressions. The principality becomes a blockage to the flow of God's energy. If God's energy cannot flow, dysfunction begins to take place in the cells. The principality can range from pain and distress to an outright breakdown in cell function.
Whenever principalities occur, the easiest and quickest method of destroying them is to call them by name and to command them to disintegrate, to melt, or to dissipate. Common principalities are ether blockers only because they never allow the energy of God to flow through them. They are resistant to change. Human beings can become principalities in God's kingdom. When they do, the only hope for moving forward is to remove them.
The Lord God Almighty El Shaddai